Is α-Casozepine Safe to Take Every Night?
- In published human trials lasting up to about 4 weeks per phase, α-casozepine was well tolerated. In the 2019 sleep trial, no one reported an adverse event while taking it.
- It is not a hormone, and no study has reported dependence or withdrawal.
- It is made from milk protein, so it is not for anyone with a milk-protein allergy.
- Data beyond a few weeks per study are limited. If you are pregnant, nursing or take medication, ask your doctor first.
What the trials report
- Kim et al., 2007: 63 women took 150 mg a day for 30 days and placebo for 30 days, with a 3-week break in between.
- Kim et al., 2019: 48 adults took 300 mg a day for 4 weeks and placebo for 4 weeks. The only adverse event in the study, itching and hives, happened in the placebo phase; no one reported one while taking the hydrolysate. Blood tests and vital signs were also checked before and after each phase.
- Chang et al., 2024: 36 adults took 600 mg a day for 2 weeks, then 300 mg for 2 weeks.
- Thiagarajah et al., 2022: 4 weeks of the hydrolysate combined with L-theanine, reported without notable adverse events.
That is a clean record, but a short one: each trial phase lasted about a month. There are no published trials of nightly use over many months, and we would rather say so than imply otherwise.
Dose
One Biopeptide capsule contains 150 mg, the lowest daily amount used in the trials above; the sleep trials used 300 to 600 mg. Take one capsule a day and do not exceed that.
Is it habit-forming?
α-casozepine is a food-derived peptide, not a drug and not a hormone. None of the trials reported dependence, and none reported withdrawal effects when people stopped, including in the crossover studies, where participants switched from the hydrolysate to placebo partway through. It is also not a sedative, so it is not meant to knock you out.
Who should not take it, or should ask first
- Milk-protein allergy: do not take it. It is made from milk protein and it is not vegan.
- Pregnant or nursing: it has not been studied in pregnancy or breastfeeding. Ask your doctor.
- Taking medication, especially any prescription medicine for sleep or mood: ask your doctor before adding any supplement.
- Children: it is for adults only.
- Anything feels off: stop taking it and contact your doctor or us at care@kincadence.com.
What is in the capsule
Per capsule: 150 mg of αS1-casein hydrolysate standardized to α-casozepine (milk protein hydrolysate). Other ingredients: hypromellose, which is the vegetable capsule, and rice flour. Contains milk. There is no melatonin, caffeine or proprietary blend. Biopeptide is made in a cGMP facility and third-party lab tested; the full label is on Ingredients & Science.
How supplements are regulated
In the US the FDA does not approve dietary supplements before sale. It regulates how they are manufactured and labeled, and the company is responsible for safety and for what it claims. That is why we print every dose, test every batch independently and describe only what the studies support.
Where Biopeptide fits
Kincadence Biopeptide is one vegetable capsule a night with 150 mg of αS1-casein hydrolysate standardized to α-casozepine. It is melatonin-free and non-hormonal, and it contains milk. Take it 30 to 60 minutes before bed. Every order carries a 90-day money-back guarantee; the conditions are in our Refund Policy.
More from Kincadence Learn
What is α-casozepine?
Where the milk peptide comes from, how it works with GABA, and what five human trials found.
Read the article →Compareα-casozepine vs melatonin
A hormone that sets your body clock versus a peptide that works with your calming system.
Read the article →TimingHow long does it take to work?
What the studies measured at one day, two weeks and four weeks, and how to give it a fair trial.
Read the article →SleepWhy do I wake up at 3 AM?
Lighter sleep late in the night, the early rise in cortisol, alcohol and age, plus what helps.
Read the article →- Kim JH, et al. European Journal of Clinical Nutrition. 2007;61(4):536–541. Crossover, placebo-controlled trial of αS1-casein hydrolysate (150 mg/day, 30 days) on stress-related symptoms in 63 women. PMID 17136040. Source
- Kim HJ, et al. Nutrients. 2019;11(7):1466. Double-blind, randomized, placebo-controlled crossover trial of αS1-casein hydrolysate (300 mg/day, 4 weeks per phase) and sleep in 48 adults. PMID 31252661. Source
- Chang C-H, et al. Clinical Nutrition. 2024. Randomized, double-blind, placebo-controlled 4-week trial of αS1-casein hydrolysate and sleep measured by polysomnography in 36 adults. PMID 39541860. Source
- Thiagarajah K, et al. Nutrients. 2022;14(3). Randomized, placebo-controlled crossover trial of αS1-casein tryptic hydrolysate combined with L-theanine on sleep quality in 39 working adults. PMID 35277011. Source
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Statements about α-casozepine reflect published research on the ingredient, not on the finished product.